• October 18, 2019

Datar Cancer Genetics Announces Positive Results With 42.9% Objective Response Rate, and 90.5% Disease Control Rate in Heavily Pre-treated Patients With Ultra-personalised Pan-cancer Treatment Protocol in the RESILIENT Trial - Odessa American: Business

e-Edition Subscribe

Datar Cancer Genetics Announces Positive Results With 42.9% Objective Response Rate, and 90.5% Disease Control Rate in Heavily Pre-treated Patients With Ultra-personalised Pan-cancer Treatment Protocol in the RESILIENT Trial

Print
Font Size:
Default font size
Larger font size

Posted: Wednesday, October 9, 2019 4:42 am

LONDON, MUMBAI, India and BAYREUTH, Germany, Oct. 9, 2019 /PRNewswire/ --

- RESILIENT Protocol captures Encyclopedic information from tumors and uses Artificial Intelligence (AI) to optimize treatments;

- Objective Response and Disease Control Comparable to or better than most Immunotherapy options;

- Unique Ultra-personalised combination of drugs already approved for cancer;

- RESILIENT Protocol commercially launched

Datar Cancer Genetics, a cancer research company, today announced positive data from the phase II/III RESILIENT trial intended to validate clinical benefit for cancer patients who have run out of treatment options under the present standard of care guidelines. The study achieved its primary and secondary end points of Objective Response Rate, Progression Free Survival and Disease Control Rate respectively.

Drug resistant cancers present a serious clinical challenge since there are virtually no treatments available and the prognosis is invariably poor. As a large proportion of all patients with advanced cancers ultimately progress towards this phase, life extending treatment options for these patients are urgently required.

The RESILIENT Protocol is designed to analyse all functional layers of a cancer cell i.e., DNA, RNA, proteins and germline genetics as also the chemoresistance/sensitivity of live tumour cells. This data is integrated through an Artificial Intelligence algorithm to derive treatment regimens which are most efficacious and yet show the least risk of toxicity.

RESILIENT is the world's first and only prospective Precision Oncology trial where drug combinations were selected on multi-analyte integration. Most prior trials based on a single molecular alteration for drug selection had dismal outcomes. 143 patients started treatment and 126 patients were evaluable as per study criteria. All patients underwent PET-CT and Brain MRI scans prior to start of treatment to establish extent of disease. Treatment response was determined by follow-up PET-CT and MRI scans.

In the majority (90.5%) of patients, further spread of cancer was effectively halted. In 42.9% of patients, treatments also led to a significant decrease in the extent of cancer. Remarkably, among the 12 patients where disease progressed, no new metastases were reported in 9 patients. There were no serious treatment related adverse events or deaths. Most patients reported stable to improved quality of life.

The data of the RESILIENT Trial is published in the peer revived oncology journal 'Oncotarget' ( https://doi.org/10.18632/oncotarget.27188 )

"The RESILIENT trial marks a watershed moment for molecular oncology as it unequivocally proves that patients who have failed even 2 to 3 lines of treatment can benefit from already approved drugs if comprehensive tumour analysis is used to guide treatments. Patients in the United Kingdom and all over the world have much to gain from the outcome of this trial," said Dr. Tim Crook, Medical Oncologist at the St. Luke's Cancer Centre, Royal Surrey County Hospital, Guildford, UK, who is one of the authors of the publication.

Datar is a leading cancer research corporation specialising in tumour analysis for better diagnosis, treatment decisions, and management of cancer. Datar's research initiatives are poised to bring about meaningful, patient-friendly and practice changing advancements in cancer treatment. Datar is also pursuing Adoptive Cell Immunotherapy for Multiple Solid Organ Cancers.

For more information please contact:

Dr. Vineet Datta - drvineetdatta@datarpgx.com

Dr Stefan Schuster - drstefanschuster@datarpgx.com

Datar Cancer Genetics – info@datarpgx.org

Related Links

https://doi.org/10.18632/oncotarget.27188

https://doi.org/10.1093/annonc/mdz268.061

https://datarpgx.com/encyclopedic-tumor-analysis-exacta/

View original content to download multimedia: http://www.prnewswire.com/news-releases/datar-cancer-genetics-announces-positive-results-with-42-9-objective-response-rate-and-90-5-disease-control-rate-in-heavily-pre-treated-patients-with-ultra-personalised-pan-cancer-treatment-protocol-in-the-resilient-trial-300934611.html

SOURCE Datar Cancer Genetics Ltd

© 2019 The Associated Press. All rights reserved. This material may not be published, broadcast, rewritten or redistributed.

Odessa, TX

Current Conditions

Clear
64°
Humidity: 59%
Winds: S at 15mph
Feels Like: 62°

Your Extended Forecast

Tomorrow

weather
High 83°/Low 56°
A few clouds. Lows overnight in the mid 50s.

friday

weather
High 87°/Low 54°
Sunshine. Highs in the upper 80s and lows in the mid 50s.

saturday

weather
High 80°/Low 54°
Abundant sunshine. Highs in the low 80s and lows in the mid 50s.
Online Features

Pet Central

pets

Having a pet is a lot of responsibility, and we’ll help by giving you lots of tips and tricks! More >>

Fitness

Fitness

Our fitness articles will help teach you how to work out with gym- and home-based exercises. More >>

Crosswords

Crosswords

Enjoy the crosswords challenge in our free daily puzzles, from the harder Sunday crossword to the quicker daily. More >>

Sudoku

Sudoku

Every Sudoku has a unique solution that can be reached logically. Enter numbers into the blank spaces so that each row, column and 3x3 box contains the numbers 1 to 9. More >>




  • ALL-ACCESS: Subscribe to our e-edition and premium website at myoaoa.com.
    You can read your daily newspaper without taking a walk to the driveway.
    Look back at yesterday's newspaper, or issues from months ago with our archive feature.
    Call circulation at 432-337-7314 to sign up today.